Aging and Hyaluronic Acid

Ageing determines a decrease of Hyaluronic Acid (HA), reduction of fibroblasts activity.

Sunekos Performa is the latest innovation in aesthetic medicine research from Sunekos Laboratories.

It is composed of low molecular weight HA and the patented cluster of Amino Acids (AA), the HY6AA formula, in a new premixed composition, thanks to an innovative production process, are allowing a significant improvement in terms of efficacy.

Sunekos Performa helps to rebuild the Extra Cellular Matrix (ECM) in a more effective and complete way, by promoting the production of:

  • Elastin (Eln). [5]
  • Collagen, including all main types of reticular collagen fibres of the dermis and Type IV and Type VII (anchoring types, plaques and fibres). [5] 

ECM model

  • Elastin
  • Collagen Type IV Anchors Plaque
  • Collagen Type VII Anchors Fibrils
  • Collagen Type IV Anchors Plaque
  • Collagen Type VII Anchors Fibrils
  • Fibronectin plays a major role in cell adhesion, and in anchoring reticular collagen fibres and cells.

Indication: wrinkles and skin laxity

Full Face

Periocular Area




“Sunekos Performa can also be used to treat periocular area, neck, décolleté and hands upon specific training with qualified personnel”


Courtesy by Elena Fasola

Courtesy by Elena Fasola

Courtesy by Mark Holmes

Courtesy by Elena Fasola


  1. Measurement of hyaluronidase activity on hyaluronic acid in presence or absence of a specific amino acid formula – Laura Tedesco and Enzo Nisoli [under publication]
  2. The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly. Carbohydr Polym – Payne WM , Svechkarev D , Kyrychenko A , Mohs AM . 2018 Feb 15;182:132-141. doi: 10.1016/j.carbpol.2017.10.054
  3. Modified hyaluronic acid based materials for biomedical applications – Tiwari S , Bahadur P.. Int J Biol Macromol. 2019 Jan;121:556-571. doi: 10.1016/j.ijbiomac.2018.10.049.
  4. Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release. – Labie H , Perro A , Lapeyre V , Goudeau B , Catargi B , Auzély R , Ravaine V. J Colloid Interface Sci. 2019 Feb 1;535:16-27. doi: 10.1016/j.jcis.2018.09.048
  5. Amino acid and hyaluronic acid mixtures differentially regulate extra cellular matrix genes in cultured human fibroblasts – B De Servi A Orlandini E Caviola M Meloni Biol Regul Homeost Agents. May-Jun 2018;32(3):517-527. PMID: 29921376)
  6. Pilot study evaluating the therapeutic effects of a new pre-mixed injectable product of low molecular weight (LMW)
    hyaluronic acid added to six amino acids (HY6AA +Formula) in facial skin aging. – Fasola E, Kutera E. J Dermat Cosmetol.

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